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发布时间:2019-06-11 13:10
Chinese scientists find how bats carry viruses without getting sick

Chinese scientists find how bats carry viruses without getting sick

ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepapersseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,",inhumansandothermammals,animmune-basedover-respo,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobeasuper-mammaltothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,connectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"TING,interfeearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  。

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